-
Award for Diggins: Best Poster CYTO 2016!
Congratulations to Kirsten Diggins for her Best Poster at CYTO 2016! This work describing Marker Enrichment Modeling (MEM) went on to be published in Nature Methods in 2017.
-
Published: Greenplate et al., Cancer Immunology Research 2016
Congratulations to Allison Greenplate & Brent Ferrell (co-corresponding) and co-authors on this publication! Greenplate AR, Johnson DB, Roussel M, Savona MR, Sosman JA, Puzanov I, Ferrell PB*, Irish JM*. Myelodysplastic Syndrome Revealed by Systems Immunology in a Melanoma Patient Undergoing Anti–PD-1 Therapy, Cancer Immunology Research 2016. PMC4891280. Pubmed. DOI. *Co-corresponding. ► This peer-reviewed research study describes a…
-
Published: Ferrell et al., PLOS One 2016
Congratulations to Brent Ferrell and co-authors on this publication! Ferrell PB, Diggins KE, Polikowsky HG, Mohan SR, Seegmiller AC, Irish JM. High-dimensional analysis of acute myeloid leukemia reveals phenotypic changes in persistent cells during induction therapy. PLOS One 2016 Apr 13;11(4). PMC4830605. Pubmed. DOI. ► This peer-reviewed research study was the first to use mass…
-
Published: Roussel et al., Human Innate Immunity 2016
Congratulations to Mikael Roussel and Allison Greenplate on this publication! Updates: Our animation of t-SNE/viSNE was selected for the book cover! The chapter introduces key ideas for Mikael’s peer-reviewed publication on myeloid cell biology, Roussel et al., Journal of Leukocyte Biology 2017. Roussel M, Greenplate AG, Irish JM. Dissecting complex cellular systems with high dimensional single…
-
Published: Polikowsky et al., Journal of Immunology 2015
Congratulations to Hannah Polikowsky, Kanutte Huse (co-corresponding), and co-authors on this publication! Polikowsky HG, Wogsland CE, Diggins KE, Huse K*, Irish JM*. Redox signaling hypersensitivity distinguishes human germinal center B cells. Journal of Immunology 2015. Pubmed. DOI. ► This peer-reviewed immunology research used phospho-specific flow cytometry and high-dimensional mass cytometry (CyTOF) to compare signaling responses in…
-
Published: Diggins et al., Methods 2015
Congratulations to Kirsten Diggins and Brent Ferrell on this publication! Diggins KE, Ferrell PB, Irish JM. Methods for discovery and characterization of cell subsets in high dimensional mass cytometry data. Methods 2015. PMC4468028. Pubmed. DOI. ► This peer-reviewed methods development research described an automated, modular workflow for unsupervised mass cytometry data analysis based on t-SNE/viSNE, clustering,…
-
Published: Leelatian et al., Methods in Molecular Biology 2015
Congratulations to Nalin Leelatian and Kirsten Diggins on this publication! Leelatian N, Diggins KE, Irish JM. Characterizing phenotypes and signaling networks of human cells by mass cytometry. Methods in Molecular Biology 2015. PMC4656023. Pubmed. DOI. ► This peer-reviewed protocol includes isolating peripheral blood mononuclear cells (PBMC), cryopreserving live PMBC, staining cells for surface mass cytometry, and measuring…
-
Published: Irish, Nature Immunology 2014
Irish JM. Beyond the age of cellular discovery. Nature Immunology 2014 Nov 14. Pubmed. DOI. ► This News & Views introduced the landmark Becher et al., Nature Immunology 2014 study and discussed how tools like single cell mass cytometry and machine learning are combining to reveal global information about cell identity for a cytomic Information…
-
Video: Dr. Brent Ferrell at Mt. Sinai Speaking on AML Mass Cytometry
October 29, 2014: P. Brent Ferrell, M.D. describes his research using mass cytometry to characterize acute myeloid leukemia (AML). This work is now published: Ferrell PB, Diggins KE, Polikowsky HG, Mohan SR, Seegmiller AC, Irish JM. High-dimensional analysis of acute myeloid leukemia reveals phenotypic changes in persistent cells during induction therapy. PLOS One 2016 Apr 13;11(4). PMC4830605. Pubmed. DOI. Published: Ferrell…
-
Doxie and Irish, Current Topics in Micro & Immuno 2014
Congratulations to Deon Doxie on this publication! Irish JM, Doxie DB. High-dimensional single-cell cancer biology. Current Topics in Microbiology & Immunology 2014. PMC4216808. Pubmed. DOI. ►This peer-reviewed review discussed how to measure cancer hallmarks in individual cells with an emphasis on quantifying altered cell signaling. It updated Irish et al., Nature Reviews Cancer 2006 and Krutzik…