{"id":1606,"date":"2022-01-20T03:58:03","date_gmt":"2022-01-20T03:58:03","guid":{"rendered":"http:\/\/localhost\/irishv01\/?page_id=1606"},"modified":"2023-08-30T19:52:32","modified_gmt":"2023-08-30T19:52:32","slug":"research","status":"publish","type":"page","link":"https:\/\/www.irishlab.org\/index.php\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n<p class=\"has-text-align-center has-medium-font-size wp-block-paragraph\">Irish lab on Pubmed: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28irish+j%5BAuthor+-+Last%5D+and+vanderbilt%29+or+%28jonathan.irish+and+vanderbilt.edu%29+or+%28irish+j%5Bauthor+-+first%5D+and+stanford%29+or+%28irish+j%5BAuthor+-+Last%5D+and+stanford%29&amp;sort=pubdate&amp;size=200\" data-type=\"link\" data-id=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28irish+j%5BAuthor+-+Last%5D+and+vanderbilt%29+or+%28jonathan.irish+and+vanderbilt.edu%29&amp;sort=pubdate\">primary research<\/a> | <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28irish+j+and+vanderbilt%29+or+%28irish+j+and+stanford%29+NOT+Irish+jc&amp;sort=pubdate&amp;size=200\" data-type=\"link\" data-id=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28irish+j+and+vanderbilt%29+or+%28irish+j+and+stanford%29+NOT+Irish+jc&amp;sort=pubdate&amp;size=200\">all research<\/a>)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Recent primary research from the Irish lab:<\/strong><\/p>\n\n\n<ul class=\"is-grid columns-2 has-dates has-authors has-excerpts wp-block-rss\"><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/40745386\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=16_WQa8IGXXcfkqQ-7dR4WMPDzFLg6bAWDQnaIT8NdYN4oW1jE&#038;fc=20230830131240&#038;ff=20260616180631&#038;v=2.20.0'>Connecting chemical structure to single cell signaling profiles<\/a><\/div><time datetime=\"2025-07-31T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">July 31, 2025<\/time> <span class=\"wp-block-rss__item-author\">by Hannah L Thirman<\/span><div class=\"wp-block-rss__item-excerpt\">A challenge in chemical biology is to study structure-activity relationships (SAR) in vivo in cells. Multiplexed activity profiling (MAP), developed for natural product discovery, is well-suited to address this challenge as it is high throughput, singlecell, and measures multiple hallmark [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/40180452\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=16_WQa8IGXXcfkqQ-7dR4WMPDzFLg6bAWDQnaIT8NdYN4oW1jE&#038;fc=20230830131240&#038;ff=20260616180631&#038;v=2.20.0'>Multiplexed cytometry for single cell chemical biology<\/a><\/div><time datetime=\"2025-04-03T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">April 3, 2025<\/time> <span class=\"wp-block-rss__item-author\">by Henry A M Schares<\/span><div class=\"wp-block-rss__item-excerpt\">Flow cytometry has great potential for screening in translational research areas due to its deep quantification of cellular features, ability to collect millions of cells in minutes, and consistently expanding suite of validated antibodies that detect cell identity and functions. [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/38826485\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=16_WQa8IGXXcfkqQ-7dR4WMPDzFLg6bAWDQnaIT8NdYN4oW1jE&#038;fc=20230830131240&#038;ff=20260616180631&#038;v=2.20.0'>Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes<\/a><\/div><time datetime=\"2024-06-03T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">June 3, 2024<\/time> <span class=\"wp-block-rss__item-author\">by Hannah L Thirman<\/span><div class=\"wp-block-rss__item-excerpt\">A central challenge in chemical biology is to distinguish molecular families in which small structural changes trigger large changes in cell biology. Such families might be ideal scaffolds for developing cell-selective chemical effectors &#8211; for example, molecules that activate DNA [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/38585888\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=16_WQa8IGXXcfkqQ-7dR4WMPDzFLg6bAWDQnaIT8NdYN4oW1jE&#038;fc=20230830131240&#038;ff=20260616180631&#038;v=2.20.0'>IL-8 Instructs Macrophage Identity in Lateral Ventricle Contacting Glioblastoma<\/a><\/div><time datetime=\"2024-04-08T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">April 8, 2024<\/time> <span class=\"wp-block-rss__item-author\">by Stephanie Medina<\/span><div class=\"wp-block-rss__item-excerpt\">Adult IDH-wildtype glioblastoma (GBM) is a highly aggressive brain tumor with no established immunotherapy or targeted therapy. Recently, CD32^(+) HLA-DR^(hi) macrophages were shown to have displaced resident microglia in GBM tumors that contact the lateral ventricle stem cell niche. Since [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/37192001\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=16_WQa8IGXXcfkqQ-7dR4WMPDzFLg6bAWDQnaIT8NdYN4oW1jE&#038;fc=20230830131240&#038;ff=20260616180631&#038;v=2.20.0'>An immunosuppressed microenvironment distinguishes lateral ventricle-contacting glioblastomas<\/a><\/div><time datetime=\"2023-05-16T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">May 16, 2023<\/time> <span class=\"wp-block-rss__item-author\">by Todd Bartkowiak<\/span><div class=\"wp-block-rss__item-excerpt\">Radiographic contact of glioblastoma (GBM) tumors with the lateral ventricle and adjacent stem cell niche correlates with poor patient prognosis, but the cellular basis of this difference is unclear. Here, we reveal and functionally characterize distinct immune microenvironments that predominate [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/36534139\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=16_WQa8IGXXcfkqQ-7dR4WMPDzFLg6bAWDQnaIT8NdYN4oW1jE&#038;fc=20230830131240&#038;ff=20260616180631&#038;v=2.20.0'>Learning cell identity in immunology, neuroscience, and cancer<\/a><\/div><time datetime=\"2022-12-19T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">December 19, 2022<\/time> <span class=\"wp-block-rss__item-author\">by Stephanie Medina<\/span><div class=\"wp-block-rss__item-excerpt\">Suspension and imaging cytometry techniques that simultaneously measure hundreds of cellular features are powering a new era of cell biology and transforming our understanding of human tissues and tumors. However, a central challenge remains in learning the identities of unexpected [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/35840326\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=16_WQa8IGXXcfkqQ-7dR4WMPDzFLg6bAWDQnaIT8NdYN4oW1jE&#038;fc=20230830131240&#038;ff=20260616180631&#038;v=2.20.0'>Systems Immunology Analyses of STAT1 Gain-of-Function Immune Phenotypes Reveal Heterogeneous Response to IL-6 and Broad Immunometabolic Roles for STAT1<\/a><\/div><time datetime=\"2022-07-15T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">July 15, 2022<\/time> <span class=\"wp-block-rss__item-author\">by Saara Kaviany<\/span><div class=\"wp-block-rss__item-excerpt\">Patients with STAT1 gain-of-function (GOF) pathogenic variants have enhanced or prolonged STAT1 phosphorylation following cytokine stimulation and exhibit increased yet heterogeneous susceptibility to infections, autoimmunity, and cancer. Although disease phenotypes are diverse and other genetic factors contribute, how STAT1 GOF [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/35710908\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=16_WQa8IGXXcfkqQ-7dR4WMPDzFLg6bAWDQnaIT8NdYN4oW1jE&#038;fc=20230830131240&#038;ff=20260616180631&#038;v=2.20.0'>Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine<\/a><\/div><time datetime=\"2022-06-17T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">June 17, 2022<\/time> <span class=\"wp-block-rss__item-author\">by Kevin J Kramer<\/span><div class=\"wp-block-rss__item-excerpt\">RNA-based vaccines against SARS-CoV-2 have proven critical to limiting COVID-19 disease severity and spread. Cellular mechanisms driving antigen-specific responses to these vaccines, however, remain uncertain. Here we identify and characterize antigen-specific cells and antibody responses to the RNA vaccine BNT162b2 [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/34350827\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=16_WQa8IGXXcfkqQ-7dR4WMPDzFLg6bAWDQnaIT8NdYN4oW1jE&#038;fc=20230830131240&#038;ff=20260616180631&#038;v=2.20.0'>Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy<\/a><\/div><time datetime=\"2021-08-05T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">August 5, 2021<\/time> <span class=\"wp-block-rss__item-author\">by Sierra M Barone<\/span><div class=\"wp-block-rss__item-excerpt\">For an emerging disease like COVID-19, systems immunology tools may quickly identify and quantitatively characterize cells associated with disease progression or clinical response. With repeated sampling, immune monitoring creates a real-time portrait of the cells reacting to a novel virus [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/33960644\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=16_WQa8IGXXcfkqQ-7dR4WMPDzFLg6bAWDQnaIT8NdYN4oW1jE&#038;fc=20230830131240&#038;ff=20260616180631&#038;v=2.20.0'>DebarcodeR increases fluorescent cell barcoding capacity and accuracy<\/a><\/div><time datetime=\"2021-05-07T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">May 7, 2021<\/time> <span class=\"wp-block-rss__item-author\">by Benjamin J Reisman<\/span><div class=\"wp-block-rss__item-excerpt\">Fluorescent cell barcoding (FCB) enables efficient collection of tens to hundreds of flow cytometry samples by covalently marking cells with varying concentration of spectrally distinct dyes. A key consideration in FCB is to balance the density of dye barcodes, the [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/32766581\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=16_WQa8IGXXcfkqQ-7dR4WMPDzFLg6bAWDQnaIT8NdYN4oW1jE&#038;fc=20230830131240&#038;ff=20260616180631&#038;v=2.20.0'>Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy<\/a><\/div><time datetime=\"2020-08-09T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">August 9, 2020<\/time> <span class=\"wp-block-rss__item-author\">by Sierra M Barone<\/span><div class=\"wp-block-rss__item-excerpt\">For an emerging disease like COVID-19, systems immunology tools may quickly identify and quantitatively characterize cells associated with disease progression or clinical response. With repeated sampling, immune monitoring creates a real-time portrait of the cells reacting to a novel virus [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/32573435\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=16_WQa8IGXXcfkqQ-7dR4WMPDzFLg6bAWDQnaIT8NdYN4oW1jE&#038;fc=20230830131240&#038;ff=20260616180631&#038;v=2.20.0'>Unsupervised machine learning reveals risk stratifying glioblastoma tumor cells<\/a><\/div><time datetime=\"2020-06-24T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">June 24, 2020<\/time> <span class=\"wp-block-rss__item-author\">by Nalin Leelatian<\/span><div class=\"wp-block-rss__item-excerpt\">A goal of cancer research is to reveal cell subsets linked to continuous clinical outcomes to generate new therapeutic and biomarker hypotheses. We introduce a machine learning algorithm, Risk Assessment Population IDentification (RAPID), that is unsupervised and automated, identifies phenotypically [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/32250555\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=16_WQa8IGXXcfkqQ-7dR4WMPDzFLg6bAWDQnaIT8NdYN4oW1jE&#038;fc=20230830131240&#038;ff=20260616180631&#038;v=2.20.0'>Training Novices in Generation and Analysis of High-Dimensional Human Cell Phospho-Flow Cytometry Data<\/a><\/div><time datetime=\"2020-04-07T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">April 7, 2020<\/time> <span class=\"wp-block-rss__item-author\">by Caroline E Roe<\/span><div class=\"wp-block-rss__item-excerpt\">This article presents a single experiment designed to introduce a trainee to multiple advanced bench and analysis techniques, including high-dimensional cytometry, profiling cell signaling networks, functional assays with primary human tissue, and single-cell analysis with machine learning tools. The trainee [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/31919622\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=16_WQa8IGXXcfkqQ-7dR4WMPDzFLg6bAWDQnaIT8NdYN4oW1jE&#038;fc=20230830131240&#038;ff=20260616180631&#038;v=2.20.0'>Mass cytometry defines distinct immune profile in germinal center B-cell lymphomas<\/a><\/div><time datetime=\"2020-01-11T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">January 11, 2020<\/time> <span class=\"wp-block-rss__item-author\">by Mikael Roussel<\/span><div class=\"wp-block-rss__item-excerpt\">Tumor-associated macrophage and T-cell subsets are implicated in the pathogenesis of diffuse large B-cell lymphoma, follicular lymphoma, and classical Hodgkin lymphoma. Macrophages provide essential mechanisms of tumor immune evasion through checkpoint ligand expression and secretion of suppressive cytokines. However, normal [&hellip;]<\/div><\/li><\/ul>\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">(all <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28irish+j%5BAuthor+-+Last%5D+and+vanderbilt%29+or+%28jonathan.irish+and+vanderbilt.edu%29+or+%28irish+j%5Bauthor+-+first%5D+and+stanford%29+or+%28irish+j%5BAuthor+-+Last%5D+and+stanford%29&amp;sort=pubdate&amp;size=200\">primary research<\/a> on Pubmed)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Recent collaborative research from the Irish lab:<\/strong><\/p>\n\n\n<ul class=\"is-grid columns-3 has-dates has-authors wp-block-rss\"><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/41915743\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1vsc_5ltFDWpFZmN0tRoB8ugodHennNs9oFUILczHbxd8yG9Bl&#038;fc=20230830133150&#038;ff=20260616180632&#038;v=2.20.0'>Spirocyclic \u03b2-lactone secondary metabolites modulate spliceosome function<\/a><\/div><time datetime=\"2026-03-31T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">March 31, 2026<\/time> <span class=\"wp-block-rss__item-author\">by Kathryn E Penton<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/41827061\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1vsc_5ltFDWpFZmN0tRoB8ugodHennNs9oFUILczHbxd8yG9Bl&#038;fc=20230830133150&#038;ff=20260616180632&#038;v=2.20.0'>Single cell protein profiling of focal cortical dysplasia in a patient requiring multiple resections<\/a><\/div><time datetime=\"2026-03-14T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">March 14, 2026<\/time> <span class=\"wp-block-rss__item-author\">by Nada A Elsayed<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/41756712\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1vsc_5ltFDWpFZmN0tRoB8ugodHennNs9oFUILczHbxd8yG9Bl&#038;fc=20230830133150&#038;ff=20260616180632&#038;v=2.20.0'>Discovery of natural products that modulate signaling in patient-derived cells<\/a><\/div><time datetime=\"2026-02-27T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">February 27, 2026<\/time> <span class=\"wp-block-rss__item-author\">by Joseph A Balsamo<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/40140496\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1vsc_5ltFDWpFZmN0tRoB8ugodHennNs9oFUILczHbxd8yG9Bl&#038;fc=20230830133150&#038;ff=20260616180632&#038;v=2.20.0'>Distinct type 1 immune networks underlie the severity of restrictive lung disease after COVID-19<\/a><\/div><time datetime=\"2025-03-27T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">March 27, 2025<\/time> <span class=\"wp-block-rss__item-author\">by Glenda Canderan<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/39643649\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1vsc_5ltFDWpFZmN0tRoB8ugodHennNs9oFUILczHbxd8yG9Bl&#038;fc=20230830133150&#038;ff=20260616180632&#038;v=2.20.0'>Multiplexed activity metabolomics for isolation of filipin macrolides from a hypogean actinomycete<\/a><\/div><time datetime=\"2024-12-06T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">December 6, 2024<\/time> <span class=\"wp-block-rss__item-author\">by Jordan T Froese<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/39310750\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1vsc_5ltFDWpFZmN0tRoB8ugodHennNs9oFUILczHbxd8yG9Bl&#038;fc=20230830133150&#038;ff=20260616180632&#038;v=2.20.0'>Defects in NK cell immunity of pediatric cancer patients revealed by deep immune profiling<\/a><\/div><time datetime=\"2024-09-23T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">September 23, 2024<\/time> <span class=\"wp-block-rss__item-author\">by Eleni Syrimi<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/39008056\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1vsc_5ltFDWpFZmN0tRoB8ugodHennNs9oFUILczHbxd8yG9Bl&#038;fc=20230830133150&#038;ff=20260616180632&#038;v=2.20.0'>Peripheral T Cell Development and Immunophenotyping of Twins with Heterozygous FOXN1 Mutations<\/a><\/div><time datetime=\"2024-07-15T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">July 15, 2024<\/time> <span class=\"wp-block-rss__item-author\">by Kelsey Voss<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/38756352\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1vsc_5ltFDWpFZmN0tRoB8ugodHennNs9oFUILczHbxd8yG9Bl&#038;fc=20230830133150&#038;ff=20260616180632&#038;v=2.20.0'>Immune-monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium<\/a><\/div><time datetime=\"2024-05-17T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">May 17, 2024<\/time> <span class=\"wp-block-rss__item-author\">by Cristina A Tentori<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/38578701\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1vsc_5ltFDWpFZmN0tRoB8ugodHennNs9oFUILczHbxd8yG9Bl&#038;fc=20230830133150&#038;ff=20260616180632&#038;v=2.20.0'>Multiparametric Single-Vesicle Flow Cytometry Resolves Extracellular Vesicle Heterogeneity and Reveals Selective Regulation of Biogenesis and Cargo Distribution<\/a><\/div><time datetime=\"2024-04-05T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">April 5, 2024<\/time> <span class=\"wp-block-rss__item-author\">by Ariana K von Lersner<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/38036712\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1vsc_5ltFDWpFZmN0tRoB8ugodHennNs9oFUILczHbxd8yG9Bl&#038;fc=20230830133150&#038;ff=20260616180632&#038;v=2.20.0'>A multicenter phase Ib trial of the histone deacetylase inhibitor entinostat in combination with pembrolizumab in patients with myelodysplastic syndromes\/neoplasms or acute myeloid leukemia refractory to hypomethylating agents<\/a><\/div><time datetime=\"2023-11-30T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">November 30, 2023<\/time> <span class=\"wp-block-rss__item-author\">by Jan Philipp Bewersdorf<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/37774400\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1vsc_5ltFDWpFZmN0tRoB8ugodHennNs9oFUILczHbxd8yG9Bl&#038;fc=20230830133150&#038;ff=20260616180632&#038;v=2.20.0'>Reply to Yasuma et\u00a0al<\/a><\/div><time datetime=\"2023-09-29T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">September 29, 2023<\/time> <span class=\"wp-block-rss__item-author\">by Allison E Norlander<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/37501683\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1vsc_5ltFDWpFZmN0tRoB8ugodHennNs9oFUILczHbxd8yG9Bl&#038;fc=20230830133150&#038;ff=20260616180632&#038;v=2.20.0'>Integrated Multi-omics Analysis of Early Lung Adenocarcinoma Links Tumor Biological Features with Predicted Indolence or Aggressiveness<\/a><\/div><time datetime=\"2023-07-28T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">July 28, 2023<\/time> <span class=\"wp-block-rss__item-author\">by Maria-Fernanda Senosain<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/37413696\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1vsc_5ltFDWpFZmN0tRoB8ugodHennNs9oFUILczHbxd8yG9Bl&#038;fc=20230830133150&#038;ff=20260616180632&#038;v=2.20.0'>Prostaglandin I2 Therapy Promotes Regulatory T Cell Generation in Patients with Pulmonary Arterial Hypertension<\/a><\/div><time datetime=\"2023-07-06T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">July 6, 2023<\/time> <span class=\"wp-block-rss__item-author\">by Allison E Norlander<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/37034287\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1vsc_5ltFDWpFZmN0tRoB8ugodHennNs9oFUILczHbxd8yG9Bl&#038;fc=20230830133150&#038;ff=20260616180632&#038;v=2.20.0'>Immune Profiling Reveals Decreases in Circulating Regulatory and Exhausted T\u00a0Cells in Human Hypertension<\/a><\/div><time datetime=\"2023-04-10T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">April 10, 2023<\/time> <span class=\"wp-block-rss__item-author\">by Matthew R Alexander<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/36824760\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1vsc_5ltFDWpFZmN0tRoB8ugodHennNs9oFUILczHbxd8yG9Bl&#038;fc=20230830133150&#038;ff=20260616180632&#038;v=2.20.0'>Dephosphorylation of 4EBP1\/2 Induces Prenatal Neural Stem Cell Quiescence<\/a><\/div><time datetime=\"2023-02-24T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">February 24, 2023<\/time> <span class=\"wp-block-rss__item-author\">by Laura C Geben<\/span><\/li><\/ul>\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28irish+j+and+vanderbilt%29+or+%28irish+j+and+stanford%29+NOT+Irish+jc&amp;sort=pubdate&amp;size=200\" data-type=\"link\" data-id=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28irish+j+and+vanderbilt%29+or+%28irish+j+and+stanford%29+NOT+Irish+jc&amp;sort=pubdate&amp;size=200\">all research<\/a> on Pubmed)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Jonathan M. Irish&#8217;s primary research from PhD &amp; postdoc:<\/strong><\/p>\n\n\n<ul class=\"is-grid columns-2 has-dates has-authors has-excerpts wp-block-rss\"><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/20543139\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1Z_Vb6O_Iw-Oia6qrAvZw5WSK6-WvBOUJ9zyCURnVheaRsKQrj&#038;fc=20230830133546&#038;ff=20260616180634&#038;v=2.20.0'>B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression<\/a><\/div><time datetime=\"2010-06-15T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">June 15, 2010<\/time> <span class=\"wp-block-rss__item-author\">by Jonathan M Irish<\/span><div class=\"wp-block-rss__item-excerpt\">Human tumors contain populations of both cancerous and host immune cells whose malignant signaling interactions may define each patient&#039;s disease trajectory. We used multiplexed phospho-flow cytometry to profile single cells within human follicular lymphoma tumors and discovered a subpopulation of [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/17105820\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1Z_Vb6O_Iw-Oia6qrAvZw5WSK6-WvBOUJ9zyCURnVheaRsKQrj&#038;fc=20230830133546&#038;ff=20260616180634&#038;v=2.20.0'>Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53<\/a><\/div><time datetime=\"2006-11-16T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">November 16, 2006<\/time> <span class=\"wp-block-rss__item-author\">by Jonathan M Irish<\/span><div class=\"wp-block-rss__item-excerpt\">Loss or mutation of the TP53 tumor suppressor gene is not commonly observed in acute myeloid leukemia (AML), suggesting that there is an alternate route for cell transformation. We investigated the hypothesis that previously observed Bcl-2 family member overexpression suppresses [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/16849466\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1Z_Vb6O_Iw-Oia6qrAvZw5WSK6-WvBOUJ9zyCURnVheaRsKQrj&#038;fc=20230830133546&#038;ff=20260616180634&#038;v=2.20.0'>Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry<\/a><\/div><time datetime=\"2006-07-20T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">July 20, 2006<\/time> <span class=\"wp-block-rss__item-author\">by Jonathan M Irish<\/span><div class=\"wp-block-rss__item-excerpt\">Differences in BCR signaling may govern outcomes as diverse as proliferation and cell death. We profiled BCR signaling kinetics in subsets of primary human B cells using flow cytometry. In the predominant population expressing IgM, BCR cross-linking led to a [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/16835385\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1Z_Vb6O_Iw-Oia6qrAvZw5WSK6-WvBOUJ9zyCURnVheaRsKQrj&#038;fc=20230830133546&#038;ff=20260616180634&#038;v=2.20.0'>Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells<\/a><\/div><time datetime=\"2006-07-13T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">July 13, 2006<\/time> <span class=\"wp-block-rss__item-author\">by Jonathan M Irish<\/span><div class=\"wp-block-rss__item-excerpt\">The B-cell receptor (BCR) transmits life and death signals throughout B-cell development, and altered BCR signaling may be required for survival of B-lymphoma cells. We used single-cell signaling profiles to compare follicular lymphoma (FL) B cells and nonmalignant host B [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/16491074\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1Z_Vb6O_Iw-Oia6qrAvZw5WSK6-WvBOUJ9zyCURnVheaRsKQrj&#038;fc=20230830133546&#038;ff=20260616180634&#038;v=2.20.0'>Mapping normal and cancer cell signalling networks: towards single-cell proteomics<\/a><\/div><time datetime=\"2006-02-24T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">February 24, 2006<\/time> <span class=\"wp-block-rss__item-author\">by Jonathan M Irish<\/span><div class=\"wp-block-rss__item-excerpt\">Oncogenesis and tumour progression are supported by alterations in cell signalling. Using flow cytometry, it is now possible to track and analyse signalling events in individual cancer cells. Data from this type of analysis can be used to create a [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/15260991\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1Z_Vb6O_Iw-Oia6qrAvZw5WSK6-WvBOUJ9zyCURnVheaRsKQrj&#038;fc=20230830133546&#038;ff=20260616180634&#038;v=2.20.0'>Single cell profiling of potentiated phospho-protein networks in cancer cells<\/a><\/div><time datetime=\"2004-07-21T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">July 21, 2004<\/time> <span class=\"wp-block-rss__item-author\">by Jonathan M Irish<\/span><div class=\"wp-block-rss__item-excerpt\">Altered growth factor responses in phospho-protein-driven signaling networks are crucial to cancer cell survival and pathology. Profiles of cancer cell signaling networks might therefore identify mechanisms by which such cells interpret environmental cues for continued growth. Using multiparameter flow cytometry, [&hellip;]<\/div><\/li><\/ul>\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">(all <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28irish+j%5BAuthor+-+Last%5D+and+vanderbilt%29+or+%28jonathan.irish+and+vanderbilt.edu%29+or+%28irish+j%5Bauthor+-+first%5D+and+stanford%29+or+%28irish+j%5BAuthor+-+Last%5D+and+stanford%29&amp;sort=pubdate&amp;size=200\">primary research<\/a> on Pubmed)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Jonathan M. Irish&#8217;s collaborative research from PhD &amp; postdoc:<\/strong><\/p>\n\n\n<ul class=\"is-grid columns-3 has-dates has-authors wp-block-rss\"><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/29217528\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1P3PNIbOiNPaDMKPQ_YML6CB3XMGpXCGF1daGyl7ZIIiFyHgVl&#038;fc=20230830134344&#038;ff=20260616180635&#038;v=2.20.0'>T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling<\/a><\/div><time datetime=\"2017-12-09T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">December 9, 2017<\/time> <span class=\"wp-block-rss__item-author\">by Sarah E Josefsson<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/28011673\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1P3PNIbOiNPaDMKPQ_YML6CB3XMGpXCGF1daGyl7ZIIiFyHgVl&#038;fc=20230830134344&#038;ff=20260616180635&#038;v=2.20.0'>Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling<\/a><\/div><time datetime=\"2016-12-25T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">December 25, 2016<\/time> <span class=\"wp-block-rss__item-author\">by June H Myklebust<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/25713363\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1P3PNIbOiNPaDMKPQ_YML6CB3XMGpXCGF1daGyl7ZIIiFyHgVl&#038;fc=20230830134344&#038;ff=20260616180635&#038;v=2.20.0'>Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation<\/a><\/div><time datetime=\"2015-02-26T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">February 26, 2015<\/time> <span class=\"wp-block-rss__item-author\">by Michael R Green<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/24983991\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1P3PNIbOiNPaDMKPQ_YML6CB3XMGpXCGF1daGyl7ZIIiFyHgVl&#038;fc=20230830134344&#038;ff=20260616180635&#038;v=2.20.0'>Joint modeling and registration of cell populations in cohorts of high-dimensional flow cytometric data<\/a><\/div><time datetime=\"2014-07-02T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">July 2, 2014<\/time> <span class=\"wp-block-rss__item-author\">by Saumyadipta Pyne<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/23297126\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1P3PNIbOiNPaDMKPQ_YML6CB3XMGpXCGF1daGyl7ZIIiFyHgVl&#038;fc=20230830134344&#038;ff=20260616180635&#038;v=2.20.0'>Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma<\/a><\/div><time datetime=\"2013-01-09T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">January 9, 2013<\/time> <span class=\"wp-block-rss__item-author\">by Michael R Green<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/23297127\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1P3PNIbOiNPaDMKPQ_YML6CB3XMGpXCGF1daGyl7ZIIiFyHgVl&#038;fc=20230830134344&#038;ff=20260616180635&#038;v=2.20.0'>High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells<\/a><\/div><time datetime=\"2013-01-09T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">January 9, 2013<\/time> <span class=\"wp-block-rss__item-author\">by June H Myklebust<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/19963681\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1P3PNIbOiNPaDMKPQ_YML6CB3XMGpXCGF1daGyl7ZIIiFyHgVl&#038;fc=20230830134344&#038;ff=20260616180635&#038;v=2.20.0'>Characterization of patient specific signaling via augmentation of Bayesian networks with disease and patient state nodes<\/a><\/div><time datetime=\"2009-12-08T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">December 8, 2009<\/time> <span class=\"wp-block-rss__item-author\">by Karen Sachs<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/19641184\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1P3PNIbOiNPaDMKPQ_YML6CB3XMGpXCGF1daGyl7ZIIiFyHgVl&#038;fc=20230830134344&#038;ff=20260616180635&#038;v=2.20.0'>Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion<\/a><\/div><time datetime=\"2009-07-31T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">July 31, 2009<\/time> <span class=\"wp-block-rss__item-author\">by Roch Houot<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/19187010\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1P3PNIbOiNPaDMKPQ_YML6CB3XMGpXCGF1daGyl7ZIIiFyHgVl&#038;fc=20230830134344&#038;ff=20260616180635&#038;v=2.20.0'>WebFlow: a software package for high-throughput analysis of flow cytometry data<\/a><\/div><time datetime=\"2009-02-04T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">February 4, 2009<\/time> <span class=\"wp-block-rss__item-author\">by Mark M Hammer<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/18835035\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1P3PNIbOiNPaDMKPQ_YML6CB3XMGpXCGF1daGyl7ZIIiFyHgVl&#038;fc=20230830134344&#038;ff=20260616180635&#038;v=2.20.0'>Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates<\/a><\/div><time datetime=\"2008-10-07T10:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">October 7, 2008<\/time> <span class=\"wp-block-rss__item-author\">by Nikesh Kotecha<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/15047199\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1P3PNIbOiNPaDMKPQ_YML6CB3XMGpXCGF1daGyl7ZIIiFyHgVl&#038;fc=20230830134344&#038;ff=20260616180635&#038;v=2.20.0'>Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications<\/a><\/div><time datetime=\"2004-03-30T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">March 30, 2004<\/time> <span class=\"wp-block-rss__item-author\">by Peter O Krutzik<\/span><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/11859408\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1P3PNIbOiNPaDMKPQ_YML6CB3XMGpXCGF1daGyl7ZIIiFyHgVl&#038;fc=20230830134344&#038;ff=20260616180635&#038;v=2.20.0'>Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line<\/a><\/div><time datetime=\"2002-02-23T11:00:00+00:00\" class=\"wp-block-rss__item-publish-date\">February 23, 2002<\/time> <span class=\"wp-block-rss__item-author\">by J S Armstrong<\/span><\/li><\/ul>\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28irish+j+and+vanderbilt%29+or+%28irish+j+and+stanford%29+NOT+Irish+jc&amp;sort=pubdate&amp;size=200\" data-type=\"link\" data-id=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28irish+j+and+vanderbilt%29+or+%28irish+j+and+stanford%29+NOT+Irish+jc&amp;sort=pubdate&amp;size=200\">all research<\/a> on Pubmed)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Google Scholar Profile for Jonathan M. Irish:<\/strong><br><a href=\"https:\/\/scholar.google.com\/citations?user=-IJndUMAAAAJ&amp;hl=en\">https:\/\/scholar.google.com\/citations?user=-IJndUMAAAAJ&amp;hl=en<\/a><br><br><strong>ORCID for Jonathan M. Irish: <\/strong><br><a href=\"https:\/\/orcid.org\/0000-0001-9428-8866\">https:\/\/orcid.org\/0000-0001-9428-8866<\/a><br><br><strong>NIH\/Pubmed URL for Jonathan M. Irish: <\/strong><br><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/myncbi\/jonathan.irish.1\/bibliography\/44179499\/public\">http:\/\/www.ncbi.nlm.nih.gov\/sites\/myncbi\/jonathan.irish.1\/bibliography\/44179499\/public<\/a><br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Irish lab on Pubmed: primary research | all research) Recent primary research from the Irish lab: (all primary research on Pubmed) Recent collaborative research from the Irish lab: (all research on Pubmed) Jonathan M. Irish&#8217;s primary research from PhD &amp; postdoc: (all primary research on Pubmed) Jonathan M. Irish&#8217;s collaborative research from PhD &amp; postdoc: [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1606","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.irishlab.org\/index.php\/wp-json\/wp\/v2\/pages\/1606","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.irishlab.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.irishlab.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.irishlab.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.irishlab.org\/index.php\/wp-json\/wp\/v2\/comments?post=1606"}],"version-history":[{"count":10,"href":"https:\/\/www.irishlab.org\/index.php\/wp-json\/wp\/v2\/pages\/1606\/revisions"}],"predecessor-version":[{"id":2678,"href":"https:\/\/www.irishlab.org\/index.php\/wp-json\/wp\/v2\/pages\/1606\/revisions\/2678"}],"wp:attachment":[{"href":"https:\/\/www.irishlab.org\/index.php\/wp-json\/wp\/v2\/media?parent=1606"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}